Nicotine Absorption From Juul, New Study

Seeking relief from nicotine addiction, some e-cigarette users turn to cigarettes - CNN

Even though McClain knows the dangers of cigarettes — lung cancer runs in his family — he thinks it might be easier to kick cigarettes than his Juul. Plus, his mom keeps warning him about the mysterious vaping-related illnesses that have sickened hundreds across the country.
So last month, McClain bought his first pack of cigarettes in years. Then he tweeted about it.
"Bought a juul to quit smoking cigarettes," he wrote, "now I'm smoking cigarettes to quit the juul." He ended with this hashtag: #circleoflife.
Click to expand...

By the time the anti-vaping zealots figure out what they've done it will be to late to undo. Actually, it probably is too late.  

So there was a cell study published recently that took human and rat lung cells and exposed them to both cigarette smoke and e-cig vapor (with and without nicotine). Dr. Farsilinos responded saying that the study was bogus based on a detail he saw in one of the charts.

What happened is they were measuring the nicotine in molarity and not in milliliters. For those of you unfamiliar, 1M = 1 molar of solute in 1 liter of a solution. So, essentially 1 molar (1M) = 1 mol/L.

Dr F. concluded that they were using concentrations of nicotine that would never been seen in real life conditions (see the link above where he explains).

Dr. F's detraction resulted from a chart that listed the following concentrations of nicotine they applied to the cells. They we

.1 mM
.5 mM
2.5 mM
5 mM
10 mM

(A mM = millimole or 1/1000th of a mole).

Now, the molar mass of nicotine is 162.23g/mol. This means that 1M of nicotine = 162.23g. Since 1M = 1mol/liter, this means that there would be 162.23g of nicotine in one liter of their solution.

Now here's where I am wondering if Dr. F messed up his calculation. A millimole = .001 M. Thus a millimole of nicotine = .16223g (let's round to .16g). That would be .16g/L.

Now .1 mM of nicotine = 160g x 0.0001 = .016g/L. And so on for the rest of the chart presented in the paper. Here would be the conversions in grams per liter:

.5 = .08g/L
2.5 = .4g/L
5 = .8g/L
10 = 1.6g/L

Now, you are probably thinking, "Yes, but you have grams per liter. We need milligrams per milliliter. Therefore, you would need to move the decimal three places to the right. Hence, .016g/L would equal 16mg/mL. Right?"

Wrong. 0.016g/L = 0.016mg/mL. It's the same. It's something we learn in elementary school called cancellation.

The density of pure nicotine is 1.01g/cm^3. This equates 1:1 with mg/mL. Thus, the density of pure nicotine (undiluted) would be 1.01g/mL or 1010mg/mL.

Dr. F, is claiming that 10 mM =1600mg/mL. This is impossible as that is more nicotine than is possible to fit into one mL, even if it was pure and undiluted. (As I said above, pure nicotine is 1010mg/mL).

I conclude that Dr. F. is wrong when he says they were using 16mg/mL, 80mg/mL, 400mg/mL, 800mg/mL, and especially 1600mg/mL (impossible), etc. He moved the decimal place over when he shouldn't have. Or perhaps I am completely wrong and talking out my behind (I am not a chemist and admit I could be totally confused about molarity and the densities and masses of the chemicals here).

I know we have chemists here. I would like it if an expert would show me the error of my ways, which I fully admit is possible. Again, I am no expert. I'm just a guy who thought that surely these researchers cannot be so silly as to use outrageous amounts of nicotine such as 1600mg/mL!  

Hey folks, I've recently created a website E-Liquid Nicotine Consumption/Absorption Calculator to calculate equivalent of how many analog 'regular' cigarettes (in terms of nicotine) we're inhaling when vaping on e-juice.

I've got some really nice feedback from you, so I've decided to give it a shot and also create a mobile version of the website. For now, it's only available for Android.

Android app is called 'E-Liquid Nicotine Calculator' and it calculates above details, as well as it allows you to estimates monthly savings of switching from regular analog cigarettes to vaping.

Please let me know what you think or how I can make it better.

You can download it from Google Play:
E-Liquid Nicotine Calculator - Android Apps on Google Play
(as long as you have an Android device it should work)

Some Screenshots:
 

Here's an interesting read... and their analysis of the data the FDA used makes sense.
In the new study, University College London health psychologist Martin Jarvis and his co-authors argue that a closer look at the survey data suggests the FDA exaggerated the threat posed by adolescent e-cigarette use.
Click to expand...

The FDA Plans To Ban Flavored E-Cigarettes Based on a Nonexistent 'Epidemic' of Adolescent Nicotine Addiction  

Folks, I apologize for the newbie questions but trust me, I've spent a lot of time reading and still have some confusion - partly because I find contradictory information everywhere. I hate when people come on forums asking questions before doing their research but I've tried.

While I've been vaping for over a year, it's been with a Juul. (3rd party pods) My flavored pod horde is about to be exhausted so here I am.

What I'm looking for is something comparable to what my Juul with 3% pods gave me - smoothness (I do NOT want a harsh throat feel like many seem to be after), availability of nice flavors, no need for a lot of nicotine, no need for 'clouds'. I was using the 3% not really because of the lower nicotine but because it wasn't as harsh as the 5-6% pods.

I guess my question is what type juice and coil resistance should I be looking for? I purchased a Smok NFix and like the device but I seem to be getting a tad bit of juice in my mouth regardless of what wattage I set it to. (I've tried multiple .8 Ohm coils and 3mg juice labeled for "subohm" use) I also seem to be getting a lot more nicotine than I'm used to.

I've also tried a Novo 2 and occasionally get that juice in my mouth but not nearly as often. I also seem to be getting a lot more nicotine than I'm used to.

Obviously I'm doing something wrong.

Another thing I'm confused about is the wide range of nicotine strengths - 3% on up to 55+%? I must be missing something because the 3% seems to be killing me, again I must be doing something wrong.

Suggestions for what I should be looking at to find something comparable to the 3% Juul?

Thanks  

So I've been mouth to lung vaping since I started vaping. Started at 24 mg with the Halo Triton and when I upgraded to the iStick and the Nautilus I lowered my nicotine down to 15 mg. It's been fine.......getting enough nicotine so I don't crave analogs, not getting too much nicotine so that I start feeling sick. Throat hit has been fine and not uncomfortable.

Yesterday I started doing lung hits with the iStick and the Nautilus and with the greater amount of vapor I can produce, I stepped the nicotine down to 12 mg since I also started to get a little lightheaded (I suppose with the greater amount of vapor I am also taking in more nicotine, even though nicotine absorption through the lungs is not supposed to be as good as through the mouth and nose). The juice that I am using is also a 70VG/30PG mix as compared to the 50/50 I was vaping before. However this morning I woke up with an irritated throat and the vape (even when switching back to mouth to lung) feels more harsh.

Do I need to step down the nicotine level even more to 6 mg? Is this normal when going from mouth to lung to direct lung hits? I'm not subohming, so I didn't expect that I would need to drop it down that much. I'm afraid that if I drop it down too much, then I'm going to have more cravings and will need to vape constantly.  

So I've heard a lot of people debating on this. Some say full mouth to lung, and hold it. Some say straight to lung and hold it.

Others say mouth to back of throat for the hit, then blow out slowly from the nose for the best absorption.


Is there any proven way to vape that gets the maximum nicotine? I always alternate but I'm curious to what everyone does/think.  

Do you think there's a standardization of vaping to cigarettes? For instance, what if, for example, 10 hits of 6mg were equal to one average cigarette in terms of nicotine crossing the blood brain barrier? How about 20 hits for 3mg liquid in an average sub ohm mod? Do you think you're delivering more nic to your brain than you were when you were a smoker?  

I was in a bar / restaurant a couple of days ago and noticed another person vaping (guy looked to be in his late 60s). The guy was using what looked like a non-adjustable EGO style stick battery with what looked like an 'old-school' Kanger T3 clearomizer on top.

I struck up a conversation with him for just a moment and asked him what type of juice he was vaping ... The guy never told me the brand or flavor, but said it was 0mg Nic when I asked him.

That was basically the end of our conversation.

My question to you folks is this .... Why would anyone keep vaping if they had no nicotine in there juice? For me, the reason I vape in the first place is to keep off cigarettes. I am obviously addicted to nicotine, and have replaced the nicotine from cigarettes for the nicotine found in my juice.

If I could wean myself completely off nicotine, I think at that point I would just give up on vaping altogether. Someday I would like to be nicotine free, but for now, I just can't see it in my future.

BTW .... I have not smoked a cigarette for 15 months, but I am still vaping on my fairly strong 16mg Nic DIY juice.  

I was just watching MSNBC and they said (paraphrased) that a study from Belgium has noted that people who smoke seem to be much less likely to get COVID, and they believe it may be because both nicotine and COVID bind to the same cell receptors (or some thing like that - I'm not a medical person lol), so they think nicotine might block COVID from being able to attach to the cell. They're looking into the connection, but say it's waaayyyy too soon to know anything for sure yet. Meanwhile, in the interim, as I refill my vape...

Here's a link to an article (there were actually several articles on google about this): Smokers 'four times less likely' to contract Covid-19, prompting nicotine patch trials on patients